Home Chemistry Heterocyclic Building Blocks Imidazoles 3-Iodoimidazo[1,2-A]Pyridine
Nucleophilic Substitution Reactions: The iodine atom is a good leaving group, and 3-iodoimidazo[1,2-a]pyridine may undergo nucleophilic substitution reactions with nucleophiles, such as amines or thiols. This could lead to the replacement of the iodine atom with the nucleophile.
Cross-Coupling Reactions: The iodine atom can participate in metal-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Stille, or Heck reactions. These reactions can be employed to introduce various substituents at the iodine position.
Reductive Dehalogenation: Under certain conditions, the iodine atom may undergo reductive dehalogenation, leading to the removal of the iodine substituent.
Metalation Reactions: The imidazole nitrogen may serve as a site for metalation reactions. This can be followed by reactions with various electrophiles.
Cyclization Reactions: The compound may undergo intramolecular cyclization reactions, especially if there are functional groups present that can participate in such processes.
Oxidation Reactions: The heterocyclic system may be susceptible to oxidation reactions under certain conditions.
Substitution Reactions on the Pyridine Ring: Depending on the reaction conditions, the pyridine ring may undergo substitution reactions, especially if there are electron-withdrawing or electron-donating groups present.
Functional Group Interconversions: Various functional groups present in the molecule may undergo interconversion reactions, depending on the reagents and conditions applied.
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Methyl 3-iodoimidazo[1,2-a]pyridine-6-carboxylate
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